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Allspice is claimed to possess antimicrobial, antioxidant, anti-inflammatory, analgesic, antipyretic, anticancer, and antitumorigenic properties (Rompelberg et al. 1996; Al-Rehaily et al. 2002; Kluth et al. 2007). It contains a multitude of potential bioactive agents that may contribute to health promotion, including flavonoids, phenolic acids, catechins, and several phenylpropanoids (Al-Rehaily et al. 2002).
The essential oil of basil possesses antimicrobial properties (Wannissorn et al. 2005). Moghaddam, Karamoddin, and Ramezani (2009) investigated the effect of basil on Helicobacter pylori and found that methanol, butanol, and n-hexane fractions of basil demonstrated antagonistic activity against the bacteria (MIC = 39-117 μg/disk). While not as potent as amoxicillin, its effectiveness raises possibilities of using individual or multiple spices as potent antimicrobials, especially in areas where commercial antibiotics are in limited supply (Moghaddam, Karamoddin, and Ramezani 2009). The anticancer properties of basil may also relate to its ability to influence viral infections.
Caraway extracts >0.13 μM significantly inhibited CYP1A1 induction, as measured by the 2,3,7-ethoxyresorufin O-deethylase assay, with roughly a tenfold suppression in enzyme activity observed at concentrations of 1.3 and 13 μM, inhibiting TCDD-dependent induction by 50%-90%, depending on the solvent used (Naderi-Kalali et al. 2005). Overall, changes in both phase I and II enzymes are consistent with the ability of caraway and its active constituent to lower chemically induced cancers.
The ability of cardamom to inhibit chemical carcinogenesis was shown by Banerjee et al. (1994), who observed cardamom oil feeding (10 μL daily for 2 weeks) caused a significant decrease in liver CYP content in Swiss albino mice (p < .05). A 30% increase in GST activity (p < .05) and sulfhydryl levels (p < .05) in the liver also accompanied the cardamom oil treatment. These observations suggest that intake of cardamom oil affects the enzymes associated with xenobiotic metabolism and may therefore have benefits as a deterrent to cancer (Banerjee et al. 1994). Cardamom has also been demonstrated to decrease azoxymethane-induced colon carcinogenesis by virtue of its anti-inflammatory, antiproliferative, and proapoptotic activities. Providing aqueous cardamom suspensions can enhance detoxifying enzyme (GST activity) and decrease lipid peroxidation (Bhattacharjee, Rana, and Sengupta 2007).
Cao, Urban, and Anderson (2008) studied the role of polyphenolic polymers from commercial cinnamon extract in immune regulation using mouse RAW264.7 macrophages. The authors examined whether cinnamon polyphenol extract (CPE) regulated immune function by affecting expression levels of genes that code for tristetraprolin (TTP/zinc finger protein 36), proinflammatory cytokines, and glucose transporter (GLUT) family proteins, and they compared these effects with that of insulin and lipopolysaccharide.
In mammals, glucose is a critically important molecule in the host immune response to injury and infection, which is facilitated by GLUT family proteins, and based on this study, cinnamon increases GLUT expression.
Clove is derived from flower buds of the Eugenia caryophyllata tree. Several bioactive components are found in clove, including tannins, terpenoids, eugenol, and acetyleugenol (Kluth et al. 2007). Cloves are native to Indonesia and are used in cuisines throughout the world. While no studies have been conducted in humans to date to evaluate use of cloves in cancer prevention, a few studies conducted in mice suggest its effectiveness, especially in modifying cellular detoxification processes.
Coriander (Coriandrum sativum) is an herb in the family Apiaceae and is native to southern Europe and northern Africa to southwestern Asia. Although all parts of the plant are edible, its fresh leaves and dried seeds are most frequently used in cooking. Coriander is a common ingredient in many foods throughout the world
Although relatively few studies focus on coriander for its anticancer properties, those that are available suggest coriander may be important (Esiyok, Otles, and Akcicek 2004).
Cumin (Cuminum cyminum) is a flowering plant in the family Apiaceae and is native to the eastern Mediterranean region and India. Thymoquinone (TQ) is the most abundant component of black cumin seed oil. TQ has been reported to exhibit antioxidant, antimicrobial, anti-inflammatory, and chemopreventive properties (Allahghadri et al. 2010; Nader, el-Agamy, and Suddek 2010) and to ameliorate B(a)P-induced carcinogenesis in the forestomach
Considerable evidence points to the ability of TQ to suppress tumor cell proliferation, including colorectal carcinoma, breast adenocarcinoma, osteosarcoma, ovarian carcinoma, myeloblastic leukemia, and pancreatic carcinoma (Gali-Muhtasib, Roessner, and Schneider-Stock 2006)
As with other spices, there is evidence that dill promotes drug detoxification mechanisms. Providing 20 mg each of carvone and anethofuran by gavage once every 2 days for a total of three doses increased GST activity in A/J mice (Zheng, Kenney, and Lam 1992). The response depended on the agent and the tissue examined. Anethofuran more than doubled the activity of the detoxifying enzyme GST in the liver (p < .005) and forestomach (p < .005), and carvone increased GST activity 78% in the forestomach (p < .05) and increased GST activity more than twofold in the liver and large intestinal mucosa (p < .05) and more than threefold in the small intestinal mucosa (p < .005; Zheng, Kenney, and Lam 1992). Because GSH helps maintain cellular oxidation-reduction balance and protects cells against free-radical species, the combination of increased GST and GSH levels results may be particularly helpful in detoxifying foreign compounds, including carcinogens.
Although garlic does not typically serve as a major source of essential nutrients, it may contribute to several dietary factors with potential health benefits, including the presence of oligosaccharides, arginine-rich proteins and, depending on soil and growing conditions, selenium and flavonoids.
Preclinical models provide rather compelling evidence that garlic and its associated components can lower the incidence of breast, colon, skin, uterine, esophagus, and lung cancers. However, evidence in human investigations is less compelling. Suppression of nitrosamine formation continues to surface as one of the most likely mechanisms by which garlic retards cancer. (Milner 2001)
Ginger also appears to have antitumorigenic properties. Several cell lines have been examined for their sensitivity to ginger. For example, alcoholic extracts of ginger inhibited tumor cell growth for Dalton’s lymphocytic ascites tumor cells and human lymphocytes at concentrations of 0.2-1 mg/mL in vitro (Unnikrishnan and Kuttan 1988). In a study of cytotoxic activities of several compounds in ginger against four tumor cell lines (A549, human lung cancer; SK-OV-3, human ovarian cancer; SK-MEL-2, human skin cancer; and HCT-15, human colon cancer), -shogaol was the most potent (ED50: 1.05–1.76 μg/mL), and -, -, -, and -gingerol displayed moderate cytotoxicity (ED50: 4.92-30.05; Kim et al. 2008). Adding -gingerol (25 μM) has been reported to inhibit proliferation in rat ascites hepatoma cells AH109A and increase apoptosis at higher concentrations (50 μM; Yagihashi, Miura, and Yagasaki 2008). Likewise, adding -shogoal (60 μM) to COLO295 cells has been reported to increase the expression of GADD153, a gene that promotes apoptosis (Chen et al. 2007)
Rosemary is a member of the family Lamiaceae, and it contains a number of potentially biologically active compounds, including antioxidants such as carnosic acid and rosmarinic acid. Other bioactive compounds include camphor (up to 20% in dry rosemary leaves), caffeic acid, ursolic acid, betulinic acid, rosmaridiphenol, and rosmanol.
Due to its high antioxidant activity, crude and refined extracts of rosemary are now widely available commercially (Ho et al. 2000). While the data are difficult to interpret, when rosemary is added along with other herbs to a balsamic vinegar preparation used in soups and salads, it appears to provide protection again oxidative stress in humans (Dragan et al. 2007).
Information gathered from the follow link.
https://www.ncbi.nlm.nih.gov/books/NBK92774/ clicik on link to read full clinical experiment info.
In speaking with the clinics it was cautioned that while eating a healthy diet consists of fruits and vegetables, you'd need to consume copious amounts to have any preventative effects. Well, these foods create glucose and eating copious amounts would create copious amounts of glucose... cancer feeds on glucose. Incorporating herbs and spices into your diet might be a consideration given what we just posted from The National Center for Biotechnology
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Health and other information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.